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A major challenge for the global nanotechnology sector is the development of safe and functional engineered nanomaterials and nano-enabled products

In this context, the application of the Safe-by-Design (SbD) concept has been adopted recently by the nanosafety community as a means to dampen human health and environmental risks, applying preventive safety measures during the design stage of a facility, process, material or product. However and despite its importance, SbD prescriptions are still in their infancy, and are hampered among other things by the lack of comprehensive data about the performance, hazard and release potential of the great variety of NEPs in use.

H2020 SbD4Nano project addresses that problem by creating a comprehensive new e-infrastructure to foster dialogue and collaboration between all actors in the supply chain for a knowledge-driven definition of SbD setups that optimize hazard, technical performance and economic costs. This will be achieved by developing

• validated rapid hazard profiling module, coupled to a new exposure-driven modelling framework aimed to reduce material toxicity.

• cost-benefit analysis algorithms designed to find the optimal solution for safety and industrially convenient technical performance of the safe-born material.

• A new software interface where product information can be exchanged between actors of the nanotechnology value chain fostering collaboration between regulators, researchers and industry.